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EC number: 439-750-2
CAS number: 183487-56-1
Background opacity: for all examined corneas (n=27), background opacity
ranged between 0 and 3, indicating that no corneas had to be excluded
from the experimental test design and replaced by another one.
In the first test, first repeat and second repeat, each negative control
cornea showed an opacity, a permeability and an in vitro score which
fell within the laboratory range of historical data. In all studies, the
corneas treated with the positive control showed a marked increase in
opacity and permeability. Imidazole (20g/g%) was detected as a very
severe eye irritant according to the historical data. Based on the
findings in the negative and positive control group, it was concluded
that the test conditions were optimal for the evaluation of the
potential of T002113 to induce opacity and permeability.
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