Titanium tetrapropanolate

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to fish

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

The target substance is hydrolytically unstable with hydrolysis half-life less than 5 minute. The hydrolysis products include 1-propanol and hydrated titanium dioxide. The ecotoxicity data of the organic parts have been well-investigated and used for read-across.

Reference 2

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

not specified

Analytical monitoring:

yes

Test organisms (species):

Pimephales promelas

Test type:

flow-through

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

ca. 4 480 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

ca. 4 630 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

yes

Conclusions:

The 96h LC50, flow through method, tested on Pimephales promelas (Fathead minnow) was 4630 to 4480 mg/l. The lower value was chosen for CSA.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

4 630 mg/L

Additional information

No studies were conducted on the target substance, titanium tetrapropanolate. As the target substance hydrolyses rapidly (half-life < 5 minutes) the intrinsic properties are related to hydrolysis products of the target substance.

On the basis that if entering the environmental, this substance will quickly dissociate to form the inorganic (poorly soluble) titanium dioxide and well-evaluated organic substances – 1-propanol.

The titanium dioxide is not considered further in this report as aquatic toxicity assessments do not apply.

LC50 (96h) values tested on Pimephales promelas were 4630-4480 mg/l for1-propanol (Geiger, et al. 1984). The lowest value of 4630 mg/l was chosen for CSA.