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EC number: 479-310-7
CAS number: -
Preliminary tolerance tests:
No irritation was observed at preliminary topical induction. Therefore,
the test item at 50% concentration was used for the topical induction as
it was judged to be well tolerated by the test system. The same
concentration was judged to be non irritant and was selected for use at
Moderate to severe erythema (score of 3) was apparent at the
sites of intradermal injection following administration of
Freund's complete adjuvant in test and control groups
respectively (anterior sites) and at sites treated with
Freund's complete adjuvant mixed with the test item or
vehicle alone (test and control group, posterior sites).
Very slight erythema (score of 1) was observed at sites
treated with the vehicle alone (control group, median
sites). Very slight to well defined erythema (scores of 1
and 2) was observed at sites treated with the test item
(test group, median sites).
No erythema was observed at sites treated with either
the test item at 50% concentration or the vehicle alone
following 48 hours of topical exposure in animals of the
test and control groups. Hardening of the treated skin sites
was seen in all animals of both groups. This reaction was
attributed to the treatment with Sodium Lauryl Sulphate,
enhanced by the subsequent treatment with the test item (or
by corn oil alone).
No response to the test item at 50% was observed in either
test or control group animals, 24 and 48 hours following a
24 hour topical exposure period. No reaction was observed to
the vehicle alone.
Body weight changes were not remarkable.
Test results indicate that the test item does not elicit a sensitization
response in the guinae pigs, being there no evidence of response at
challenge following a period of induction exposure to the test item.
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