Registration Dossier
Registration Dossier
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EC number: 240-968-3 | CAS number: 16919-19-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In a period of 10 days rats were rubbed with oingment (containing 50% Natriumhydrofluosilicate in plant oil or Natriumhydrofluosilicate and Ammoniumhydrofluosilicate) on 2/3 of their tails.
- GLP compliance:
- no
- Test type:
- other:
Test material
- Reference substance name:
- Ammonium hexafluorosilicate
- EC Number:
- 240-968-3
- EC Name:
- Ammonium hexafluorosilicate
- Cas Number:
- 16919-19-0
- Molecular formula:
- F6Si.2H4N
- IUPAC Name:
- diammonium hexafluorosilicate
- Test material form:
- solid: particulate/powder
1
- Specific details on test material used for the study:
- Natriumhydrofluosilicic or Natriumfluosilicate and Ammoniumfluosilicate
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- other: oingment with plant oil
- Details on dermal exposure:
- The 2/3 of the tails of rats were rubbed with oingment.
- Duration of exposure:
- 10 days
- Doses:
- 50 % test substance in plant oil
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Remarks on result:
- other: dermal toxicity
- Mortality:
- rats treated with natruimhydrofluosilicate only died within 5 days.
- Clinical signs:
- In rats treated with natriumhydrofluosilicate and ammoniumhydrofluosilicate no letality occured, but the animals were sluggish and inactive.
Applicant's summary and conclusion
- Interpretation of results:
- other:
- Conclusions:
- The test substance is toxic to the skin.
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