β-Alanine, N-coco alkyl derivs.

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

27 September 1995 to 29 September 1995

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

no

GLP compliance:

yes

Analytical monitoring:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Test temperature:

20 ± 2 °C

pH:

- pH 7.8 to 7.9 (0 h)
- pH 7.8 to 8.2 (48 h)

Nominal and measured concentrations:

Nominal concentrations of 0.30, 0.60, 1.25, 2.5, 5.0 and 10 mg/L

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

1.2 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Conclusions:

The 48 hour EC50 value of Lakeland ACP 70 to Daphnia magna was estimated as 1.2 mg/L.

Executive summary:

The 48 hour EC50 value of Lakeland ACP 70 to Daphnia magna was estimated as 1.2 mg/L. The highest no-observed effect concentration (HNEC) after 48 hours was 0.60 mg/I. The lowest test concentration which immobilised all twenty Daphnia (LOEC) within 48 hours was 2.5 mg/I. Water quality measurements of the test solutions were within acceptable limits. None of the twenty control Daphnia, maintained in dilution water, was immobilised during the study and this indicates an acceptable level of health of the test organisms cultured under the test conditions.

Reference 2

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: ISO 14669 (Water quality - determination of acute lethal toxicity to marine copepods (Copepoda, Crustacea)

Version / remarks:

1999(E)

Deviations:

no

GLP compliance:

yes

Analytical monitoring:

no

Test organisms (species):

other: Acartia tonsa

Test type:

static

Water media type:

saltwater

Limit test:

no

Total exposure duration:

48 h

Test temperature:

Not reported

pH:

Not reported

Nominal and measured concentrations:

Nominal concentrations of 0.1 to 1.0 mg/L

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

0.1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Conclusions:

Exposure of Acartia tonsa to the substance gave LC50 (48 h) 1.0 mg/L and the NOEC value was reported as 0.1 mg/L.

Executive summary:

A sample of ACP 70 was assessed for potential toxicity to the marine copepod Acartia tonsa in a static test over 48 hours according to the draft method ISO 14669: 1999(E). Nominal test concentrations of ACP 70 were prepared over the range 0.10 mg 1-1 to 1.0 mg/L. Acartia tansa were exposed to the test concentrations in order to determine the concentration which killed 50% of the copepods over 48 hours (LCSO). Results were reported as LC50 (48 h) 1.0 mg/L and the NOEC value was reported as 0.1 mg/L.

Description of key information

Results are available for one species of freshwater invertebrate and one species of marine invertebrate.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

1.2 mg/L

Marine water invertebrates

Marine water invertebrates

Effect concentration:

1 mg/L