Registration Dossier
Registration Dossier
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EC number: 216-407-3 | CAS number: 1576-35-8
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
- Justification for type of information:
- TSH has a low vapour pressure and the use as a blowing agent does not lead to the formation of aerosols or particles.
Due to the possible breakdown product from hydrolysis, a precautionary approach is used.
No reliable experimental data is available for toluene-4-sulphonohydrazide (TSH). However, data on the presumed breakdown product of Toluene-4-sulphonohydrazid, hydrazine (CAS No. 302-01-2) shows an LC50 of 570 ppm (0.759 mg/L); and has a harmonized classification for Acute Tox. 3, H331 (toxic if inhaled). Based on the acute toxicity of the presumed breakdown product, hydrazine, it is considered appropriate to classify toluene-4-sulphonohydrazide (TSH) as Acute Tox. 3, H331 without further testing.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
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