Registration Dossier
Registration Dossier
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EC number: 216-407-3 | CAS number: 1576-35-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- No data is available for Toluene-4-sulphonohydrazide (TSH). However, QSAR prediction data shows that oral LD50 in rats and mice is 320 mg/kg bw/day and 1300 mg/kg bw/day, respectively. The predictions had a moderate prediction quality i.e., 0.59 and 0.52 for rats and mice, respectively.
Data source
Reference
- Reference Type:
- other: Q(SAR) prediction report
- Title:
- (Q)SAR predicted profile for toluene-4-sulphonohydrazide
- Year:
- 2 022
- Bibliographic source:
- Danish Q(SAR) database
- Report date:
- 2022
Materials and methods
- Principles of method if other than guideline:
- - Software tool(s) used including version: Danish Q(SAR) database
Test material
- Reference substance name:
- Toluene-4-sulphonohydrazide
- EC Number:
- 216-407-3
- EC Name:
- Toluene-4-sulphonohydrazide
- Cas Number:
- 1576-35-8
- Molecular formula:
- C7H10N2O2S
- IUPAC Name:
- toluene-4-sulphonohydrazide
- Test material form:
- solid: particulate/powder
Constituent 1
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
Results and discussion
- Preliminary study:
- Rat Oral LD50 predicted to be 320 mg/kg bw/day. Reliability index of 0.59 (moderate prediction quality)
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 320 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- LD50 from 250 to 320 mg/kg bw
- Executive summary:
No data is available for Toluene-4-sulphonohydrazide (TSH). However, QSAR prediction data shows that oral LD50 in rats and mice is 320 mg/kg bw/day and 1300 mg/kg bw/day, respectively. The predictions had a moderate prediction quality i.e., 0.59 and 0.52 for rats and mice, respectively.
In suppport, data from a recent study conducted according to OECD guideline 489 (in vivo mammalian alkaline comet assay) where Wister rats were treated by oral gavage with the Toluene-4-sulphonohydrazide, mortality was observed at a dose of 250 mg/kg 02.bw/day in males.Based on this TSH should be classified as Acute tox 3
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