Registration Dossier
Registration Dossier
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EC number: 276-771-4 | CAS number: 72705-26-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A 48-h static acute toxicity test on neonates (< 24 h old) of Daphnia magna was performed under GLP conditions according to OECD 202 (2004). The EC50 value after 48 h of exposure is higher than 117 mg/L.
Key value for chemical safety assessment
Additional information
A 48-h static acute toxicity test on neonates (< 24 h old) of Daphnia magna was performed under GLP conditions according to OECD 202 (2004). The test was performed in one limit test item concentration 117 mg/L (what corresponds with 100 mg/L of main ingredient) (limit test) plus the control. The test item concentration used in the definitive test was determined on the basis of the preliminary test results. Additional control with ammonium added was done to ensure that the impact of ammonium on test organism will not cause biological response. In the samples collected at exposure initiation the determined main ingredient concentration was 95.5% of nominal concentration. Therefore, the results confirm correct preparation of the test item concentration. In the samples collected at exposure termination the determined main ingredient concentration was 93.6% of nominal concentration. Therefore, the test item concentration was stable under test conditions. Eight replicates of the test item concentration 117 mg/L and the controls with five Daphnia magna per replicate were used. Daphnia magna were observed for immobilization after 24 and 48 h of exposure. In the samples collected at exposure termination the determined main ingredient concentration was 93.6% of nominal concentration. Therefore, the test item concentration was stable under test conditions. After 48 hours during exposure in the test item concentration 117 mg/L and the controls no immobilization of Daphnia magna was observed. Since the immobilization of Daphnia magna was less than 10% no statistical analysis was needed. The EC50 value after 48 h of exposure is higher than 117 mg/L.
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