(R)-6-(isopropyl)-3-methylcyclohex-2-en-1-one

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

20 to 24 February 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Remarks:

Staatliches Gewerbeaufsichtsamt Hildesheim

Type of method:

flask method

Water solubility:

2.479 g/L

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

pH:

ca. 5

 Temperature at Pre-Incubation (30 °C) and Thermostatisation Phase (20 °C) (measured hourly)

Intended temperature [°C]	Measured temperature [°C]
	Min	Max	Mean value ± SD
30.0 ± 0.5	29.97	30.28	30.06 ± 0.09
20.0 ± 0.5	19.96	20.20	20.00 ± 0.05

Min = Minimum temperature measured

Max = Maximum temperature measured

SD = Standard deviation

 

Check of the pH-value

The pH-values were determined with the remaining test item mixtures in the original test vessels, which were kept constant at 20 ± 0.5 °C.

 

Test temperature [°C]	Pre-incubation time [hi	Replicate	Measured pH	Mean value
20	24	1	4.709	5.0
		2	4.901
	48	1	5.040
		2	5.032
	72	1	5.474
		2	4.866
		Control	6.824	-

 

Check of the Tyndall-Effect

All samples were checked negative for a Tyndall effect.

 

Water solubility results

No significant signals were obtained for the control sample.

 

Water Solubility Results at 20 °C for test item

 

Preincubation time	Replicate No.	Test item [g/L]
		Concentration [1]	Mean
24 h	1	2.463	2.482
	2	2.501
48 h	1	2.487	2.474
	2	2.461
72 h	1	2.486	2.482
	2	2.479
Mean (24 - 72 h)			2.479
Deviation [%] (24 - 72 h) [2]			0.3

[1] Mean value of two injections, dilution factor of 100 and exact weight of the standard taken into account.

[2] Calculated according to formula: Deviation [%] = 100 * (max value – min value) / min value.

Conclusions:

A water solubility value of 2.479 g/L (at 20 °C, pH ca. 5.0) was determined for the test substance according to OECD 105.

Description of key information

Water solubility: 2.479 g/L at 20 °C, pH ca. 5.0 (OECD 105, flask method)

Key value for chemical safety assessment

Water solubility:

2.479 g/L

at the temperature of:

20 °C