Registration Dossier
Registration Dossier
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EC number: 224-957-0 | CAS number: 4573-50-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 to 24 February 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Staatliches Gewerbeaufsichtsamt Hildesheim
- Type of method:
- flask method
- Water solubility:
- 2.479 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- ca. 5
- Conclusions:
- A water solubility value of 2.479 g/L (at 20 °C, pH ca. 5.0) was determined for the test substance according to OECD 105.
Reference
Temperature at Pre-Incubation (30 °C) and Thermostatisation Phase (20 °C) (measured hourly)
Intended temperature [°C] |
Measured temperature [°C] |
||
Min |
Max |
Mean value ± SD |
|
30.0 ± 0.5 |
29.97 |
30.28 |
30.06 ± 0.09 |
20.0 ± 0.5 |
19.96 |
20.20 |
20.00 ± 0.05 |
Min = Minimum temperature measured
Max = Maximum temperature measured
SD = Standard deviation
Check of the pH-value
The pH-values were determined with the remaining test item mixtures in the original test vessels, which were kept constant at 20 ± 0.5 °C.
Test temperature [°C] |
Pre-incubation time [hi |
Replicate |
Measured pH |
Mean value |
20 |
24 |
1 |
4.709 |
5.0 |
2 |
4.901 |
|||
48 |
1 |
5.040 |
||
2 |
5.032 |
|||
72 |
1 |
5.474 |
||
2 |
4.866 |
|||
Control |
6.824 |
- |
Check of the Tyndall-Effect
All samples were checked negative for a Tyndall effect.
Water solubility results
No significant signals were obtained for the control sample.
Water Solubility Results at 20 °C for test item
Preincubation time |
Replicate No. |
Test item [g/L] |
|
Concentration [1] |
Mean |
||
24 h |
1 |
2.463 |
2.482 |
2 |
2.501 |
||
48 h |
1 |
2.487 |
2.474 |
2 |
2.461 |
||
72 h |
1 |
2.486 |
2.482 |
2 |
2.479 |
||
Mean (24 - 72 h) |
|
2.479 |
|
Deviation [%] (24 - 72 h) [2] |
|
0.3 |
|
[1] Mean value of two injections, dilution factor of 100 and exact weight of the standard taken into account.
[2] Calculated according to formula: Deviation [%] = 100 * (max value – min value) / min value.
Description of key information
Water solubility: 2.479 g/L at 20 °C, pH ca. 5.0 (OECD 105, flask method)
Key value for chemical safety assessment
- Water solubility:
- 2.479 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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