9,10-Anthracenedione, 1,4-diamino-, N,N'-mixed 2-ethylhexyl and hexyl and octyl derivs.

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species, other

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

Estimated data generated using the EPI Suite program developed by the USEPA.

Qualifier:

according to guideline

Guideline:

other: Modeling database

Principles of method if other than guideline:

Prediction done using BCFBAF (v3.01) model

GLP compliance:

no

Radiolabelling:

no

Vehicle:

no

Test organisms (species):

other: Fish

Route of exposure:

aqueous

Test type:

flow-through

Water / sediment media type:

natural water: freshwater

Test temperature:

25°C

Reference substance (positive control):

no

Key result

Temp.:

25 °C

Type:

BCF

Value:

3.162 L/kg

Basis:

whole body w.w.

Calculation basis:

other: estimated

Details on results:

BCFBAF Program (v3.00) model of EPI suite used to predict the BCF value of test chemical. The bioconcentration factor (BCF) for test chemical was predicted to be 3.162 L/kg wet-wt at 25°C.

Validity criteria fulfilled:

not specified

Conclusions:

BCFBAF Program (v3.00) model of EPI suite used to predict the BCF value of test chemical. The bioconcentration factor (BCF) for test chemical was predicted to be 3.162 L/kg wet-wt at 25°C.

Executive summary:

Using BCFBAF Program (v3.00) model of EPI suite the estimated bioconcentration factor (BCF) for test chemical was predicted to be 3.162 L/kg wet-wt at 25°C which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical is non bioaccumulative in food chain.

Description of key information

BCFBAF Program (v3.00) model of EPI suite used to predict the BCF value of test chemical. The bioconcentration factor (BCF) for test chemical was predicted to be 3.162 L/kg wet-wt at 25°C.

Key value for chemical safety assessment

BCF (aquatic species):

3.162 L/kg ww

Additional information

Following different studies includes estimated study for the target chemical and experimental study for read-across analogues which is extracted by using mechanistic approach and functionally and structurally similar to the target chemical to observe the bioaccumulation of test chemical:

Using BCFBAF Program (v3.00) model of EPI suite the estimated bioconcentration factor (BCF) for test chemical was predicted to be 3.162 L/kg wet-wt at 25°C which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical is non bioaccumulative in food chain.

Bioaccumulation study was conducted for evaluating the bioconcentration factor (BCF value) of test chemical. The study was performed for 6 weeks. Cyprinus carpio was used as a test organism for the study. Test organisms were exposed to different nominal concentration of 0.05 mg/L and 0.005 mg/L. Study was conducted in flow through system for 6 weeks. Vehicle used in the test was Dimethyl sulfoxide and Polyvinylpyrrolidone at different concentrations. Range finding study was performed on Rice fish (Oryzias latipes) to determine LC50 value for 48h which was determined to be >= 30.0 mg/L. The bioconcentration factor (BCF value) of test chemical on Cyprinus carpio was determined to be in the range of 27-43 L/Kg  and 18-46 L/Kg at a conc. of 0.05 and 0.005 mg/L, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.

Bioaccumulation study was conducted for evaluating the bioconcentration factor (BCF value) of test chemical. The study was performed for 8 weeks. Cyprinus carpio was used as a test organism for the study. Test organisms were exposed to different nominal concentration of 0.03 mg/L and 0.003 mg/L. Study was conducted in flow through system for 8 weeks. Vehicle used in the test was Dimethyl sulfoxide and Polyvinylpyrrolidone at different concentrations. Range finding study was performed on Rice fish (Oryzias latipes) to determine LC50 value for 48h which was determined to be >= 30.0 mg/L. The bioconcentration factor (BCF value) of test chemical on Cyprinus carpio was determined to be in the range of 50-150 L/Kg  and 55-137 L/Kg at a conc. of 0.03 and 0.003 mg/L, respectively which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.

On the basis of above values, it is indicating that the test chemical is not expected to bioaccumulate in the food chain.