Registration Dossier
Registration Dossier
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EC number: 617-898-0 | CAS number: 866462-52-4
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The determination was carried out using the HPLC Method designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
The test system consisted of a high performance liquid chromatograph with an appropriate detector. A reverse phase HPLC column with a very low percentage of polar groups was used and the mobile phase contained at least 25 % aqueous phase.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 617-898-0
- EC Number:
- 617-898-0
- Cas Number:
- 866462-52-4
- Molecular formula:
- C17 H21 N O5
- IUPAC Name:
- 617-898-0
- Test material form:
- solid: particulate/powder
- Details on test material:
- Off white powder
Constituent 1
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. 1.64
- Temp.:
- 30 °C
- Remarks on result:
- other: The test item has no means of ionization, within biological range, therefore manipulation of the mobile phase pH was unnecessary.
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of the test item has been determined to be 43.4, log10 Pow 1.64.
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