Registration Dossier
Registration Dossier
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EC number: 271-896-0 | CAS number: 68611-47-2
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Silicic acid (H4SiO4), zinc salt (1:2), manganese-doped
- EC Number:
- 271-896-0
- EC Name:
- Silicic acid (H4SiO4), zinc salt (1:2), manganese-doped
- Cas Number:
- 68611-47-2
- Molecular formula:
- Zn2SiO4:Mn
- IUPAC Name:
- Silicic Acid (H4SiO4), Zinc Salt (1: 2), Manganese-Doped
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA:J
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- propylene glycol
- Concentration:
- 12.5%, 25% and 50%
- No. of animals per dose:
- 4
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
- Positive control results:
- SI 3.6
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Value:
- 0.5
- Test group / Remarks:
- For the mice treated at 12.5%
- Parameter:
- SI
- Value:
- 0.5
- Test group / Remarks:
- For the mice treated at 25%
- Parameter:
- SI
- Value:
- 0.8
- Test group / Remarks:
- For the mice treated at 50%
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
