Registration Dossier
Registration Dossier
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EC number: 271-896-0 | CAS number: 68611-47-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Silicic acid (H4SiO4), zinc salt (1:2), manganese-doped
- EC Number:
- 271-896-0
- EC Name:
- Silicic acid (H4SiO4), zinc salt (1:2), manganese-doped
- Cas Number:
- 68611-47-2
- Molecular formula:
- Zn2SiO4:Mn
- IUPAC Name:
- Silicic Acid (H4SiO4), Zinc Salt (1: 2), Manganese-Doped
Constituent 1
Test animals / tissue source
- Species:
- other: Reconstructed Human Cornea-like epithelium (RHCE)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Duration of treatment / exposure:
- 6 h
- Duration of post- treatment incubation (in vitro):
- 30 min
Results and discussion
In vitro
Results
- Irritation parameter:
- other: viability
- Value:
- 101.16
- Negative controls validity:
- valid
- Remarks:
- 100
- Positive controls validity:
- valid
- Remarks:
- 39.12
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- other: non irritant
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