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EC number: 238-523-3
CAS number: 14516-71-3
In an in vitro skin corrosion assay in a human epidermal model EpiDerm
(17-164), water-moistened reconstructed human epidermis (RhE) tissue was
exposed to 25 mg of UV-1084 (99.1%) for 3 and 60 minutes. Sterile water
was used for the negative control and 8N KOH was used for the positive
control. After rinsing, tissues were incubated with MTT for 3 hours and
then extracted with isopropyl alcohol for 2 hours at room temperature
with shaking. The OD570 of isopropyl alcohol extracts was measured on a
spectrophotometer. Relative cell viability was calculated for each
tissue as % of the mean viability of the negative control tissues.
The colour of the test substance did not interfere with the endpoint.
The test substance is not directly MTT reducing. The negative control
gave the appropriate response. The average viability of tissues treated
with the test substance UV-1084 was 107 % of the negative control
average value after 3 minutes treatment and 93.4 % after 60 minutes
treatment. The average viability of positive control tissues at 3 and 60
minutes was 8.5% and 3.9%, respectively. The test substance UV1084 was
non-corrosive in the EpiDermTM model.
This in vitro skin corrosion study in the human epidermal model
EpiDermTM is acceptable and satisfies the guideline requirement for an
OECD 431 study.
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