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EC number: 946-433-7
CAS number: -
activity of Petitgrain Oil Paraguay was evaluated in accordance with
OECD 471 guideline and according to GLP principles. The test was
performed as a standard plate incorporation assay, both in the absence
and presence of S9-mix up to and including 5000 μg/plate. Cytotoxicity,
as evidenced by a decrease in the number of revertants, was observed
from 1500 or at 5000 μg/plate. Precipitation was observed at 5000
μg/plate. Adequate negative and positive controls were included. The
substance did not induce a significant dose-related increase in the
number of revertant (His+) colonies in each of the five S. typhimurium
tester strains (TA1535, TA1537, TA98, TA100 WP2 uvrA), both in the
absence and presence of S9 -metabolic activation. These results were
confirmed in an independently repeated experiment. Based on the results
of this study it is concluded that Petitgrain oil citrus aurantium was
determined to be not mutagenic and does not need to be classified for
mutagenicity in accordance with the criteria outline in Annex I of CLP
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