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EC number: 946-433-7
CAS number: -
Historical control data
SD = Standard deviation
n = Number of observations
The above mentioned historical control data range of the controls were
obtained by collecting all data over the period of Aug 2014 to Aug 2017.
irritation potential of Petitgrain oil (citrus aurantium) was measured
by its ability to induce opacity and increase permeability in an
isolated bovine cornea using the Bovine Corneal Opacity and Permeability test
(BCOP test). The study procedures described in this report were based on
the most recent OECD test
guideline 437. Petitgrain oil (citrus aurantium) was applied as received
to the test system, and induced a
mean in vitro irritancy score of 3.9 (first experiment) and 5.8 (second
experiment) after 10 minutes of treatment. The negative control
responses for opacity and permeability were less than the upper limits
of the laboratory historical range indicating that the negative control
did not induce irritancy on the corneas. The mean in vitro irritancy
score of the positive control (Ethanol) was within two standard
deviations of the current historical positive control mean. It was
therefore concluded that the test conditions were adequate and that the
test system functioned properly. Under the conditions of this study,
Petitgrain Oil (citrus aurantium) induced an IVIS > 3≤55,
therefore no prediction on the classification can be made in accordance
with the criteria outlined in Annex I of the CLP regulations
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