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EC number: 229-539-1 | CAS number: 6598-63-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Human & Environmental Risk Assessment on ingredients of European household cleaning products Substance: Fluorescent Brightener FWA-5 (CAS 27344-41-8)
- Author:
- Human & Environmental Risk Assessment on ingredients of European household cleaning products Substance
- Year:
- 2 003
- Bibliographic source:
- HERA targeted risk assessment of FWA-5, May, 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- To evaluate skin irritation potential of Disodium 2,2'-([1,1'-biphenyl]-4,4'-diyldivinylene)bis(benzenesulphonate on New Zealand White rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Disodium 2,2'-([1,1'-biphenyl]-4,4'-diyldivinylene)bis(benzenesulphonate)
- EC Number:
- 248-421-0
- EC Name:
- Disodium 2,2'-([1,1'-biphenyl]-4,4'-diyldivinylene)bis(benzenesulphonate)
- Cas Number:
- 27344-41-8
- Molecular formula:
- C28H22O6S2.2Na
- IUPAC Name:
- Disodium 2,2'-([1,1'-biphenyl]-4,4'-diyldivinylene)bis(benzenesulphonate
- Details on test material:
- IUPAC name: Disodium 2,2'-([1,1'-biphenyl]-4,4'-diyldivinylene)bis(benzenesulphonate
commen name: Tinopal cbs-X
Molecular formula :C28H22O6S2.2Na
Molecular weight :562.572 g/mol
Substance type: organic
physical state: yellow powder
InChIKey :SQAKQVFOMMLRPR-UHFFFAOYSA-N
Smiles :S(c1c(\C=C/c2ccc(c3ccc(\C=C/c4c(cccc4)S(O)(=O)=O)cc3)cc2)cccc1)(=O)(=O)O
Constituent 1
- Specific details on test material used for the study:
- IUPAC name: Disodium 2,2'-([1,1'-biphenyl]-4,4'-diyldivinylene)bis(benzenesulphonate
commen name: Tinopal cbs-X
Name of test material (as cited in study report): Fluorescent Brightener FWA-5
Molecular formula :C28H22O6S2.2Na
Molecular weight :562.572 g/mol
Substance type: organic
physical state: yellow powder
InChIKey :SQAKQVFOMMLRPR-UHFFFAOYSA-N
Smiles :S(c1c(\C=C/c2ccc(c3ccc(\C=C/c4c(cccc4)S(O)(=O)=O)cc3)cc2)cccc1)(=O)(=O)O
Purity:>98.5%
impurity:Approx 2%
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
New zealand white male rabbits were used.
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 2.2 to 2.3 kg.
- Fasting period before study: no data
- Housing: individually in metal cages
- Diet (e.g. ad libitum): standard pelleted rabbit food ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±3°C
- Humidity (%):30-70%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 hours light cycle day
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Amount / concentration applied:
- Amount- 0.5ml
Concentration – 21.3% - Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 1, 24, 48 and 72 hours
- Number of animals:
- total=3
- Details on study design:
- - Area of exposure: 6 sq. cm
- % coverage: no data
- Type of wrap if used: Gauze patch
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: 4 hrs
SCORING SYSTEM: respective mean values for each type of lesion
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- fully reversible within: 24 hrs
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- At one hour, erythema was observed in each animal (one with grade 2; two with grade 1) as was grade 1 edema. At 24-hours, no signs of erythema or edema were observed and the calculated primary irritation index was 0.00 (max.8.0).
- Other effects:
- At one hour, erythema was observed in each animal (one with grade 2; two with grade 1) as was grade 1 edema.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- (Disodium 2,2'-([1,1'-biphenyl]-4,4'-diyldivinylene)bis(benzenesulphonate) when applied on the skin of New Zealand White rabbits in concentration 0.5ml of 21.3% in water . No corrosive effects were noted on the treated skin of any animal at observation time. (Disodium 2,2'-([1,1'-biphenyl]-4,4'-diyldivinylene)bis(benzenesulphonate) is considered to be not irritating to rabbit skin.
- Executive summary:
(Disodium 2,2'-([1,1'-biphenyl]-4,4'-diyldivinylene)bis(benzenesulphonate) was used as a test material to evaluate its skin sensitization potential.
The test was performed on 3 young adult male New Zealand White rabbits weighing 2.2 to 2.3 kg. They were housed individually in metal cages, were kept at a constant room temperature of 20±3 °C, at a relative humidity of 30-70%, and on a 12 hours light cycle day. The animals received ad libitum standard pelleted rabbit food (Nafag No. 814; Gossau, Switzerland) and water. Prior to treatment they were acclimatized for a minimum of 5 days. The test article was applied as a liquid formulation containing 21.3% FWA-5 in water.
About 24-hours before treatment an area of about 6 sq. cm was shaved on both flanks of each rabbit. Gauze patch of 2.5 x 2.5 cm covered with 0.5 mL of the test material was applied to one flank and a control patch to the contralateral flank. The patches were covered with an impermeable material and were fastened to the body of the rabbit with adhesive tape. The duration of treatment was four hours. The scoring of skin reaction was performed 1, 24, 48 and 72 hours after removal of the dressing. These scores were used in calculating the respective mean values for each type of lesion.
At one hour, erythema was observed in each animal (one with grade 2; two with grade 1) as was grade 1 edema. At 24-hours, no signs of erythema or edema were observed and the calculated primary irritation index was 0.00 (max.8.0). The substance did not cause any staining of the treated skin. No corrosive effects were noted on the treated skin of any animal at any observation time.
(Disodium 2,2'-([1,1'-biphenyl]-4,4'-diyldivinylene)bis(benzenesulphonate) when applied on the skin ofNew Zealand White rabbits in concentration 0.5ml of 21.3% in water . No corrosive effects were noted on the treated skin of any animal at observation time.(Disodium 2,2'-([1,1'-biphenyl]-4,4'-diyldivinylene)bis(benzenesulphonate) is considered to be not irritating to rabbit skin.
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