Registration Dossier
Registration Dossier
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EC number: 219-307-8 | CAS number: 2408-20-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance Material Monograph for Allyl butyrate
- Author:
- Edited by D. L. J. Opdyke
- Year:
- 1 977
- Bibliographic source:
- Food and Cosmetics Toxicology, Volume 15, Issue 6, December 1977, Pages 613-614
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the dermal irritation potential of allyl butyrate in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Allyl butyrate
- EC Number:
- 218-129-8
- EC Name:
- Allyl butyrate
- Cas Number:
- 2051-78-7
- Molecular formula:
- C7H12O2
- IUPAC Name:
- 2-Propen-1-yl butanoate
- Test material form:
- liquid
- Details on test material:
- Name of the test chemical: 2-Propen-1-yl butanoate
Common name: Allyl butyrate
Molecular Formula: C7H12O2
Molecular Weight: 128.17 g/mol
Substance Type: Organic
Physical State: Liquid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical: 2-Propen-1-yl butanoate
Common name: Allyl butyrate
Molecular Formula: C7H12O2
Molecular Weight: 128.17 g/mol
Substance Type: Organic
Physical State: Liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- full strength (undiluted) test chemical
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- no data available
- Details on study design:
- no data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritant / corrosive response data:
- Moderate irritation was observed
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Allyl butyrate was moderately irritating to rabbit skin after 24 hours of exposure.
- Executive summary:
A skin irritation study was performed on rabbits to assess the irritation potential of allyl butyrate.Undiluted allyl butyrate was applied under occlusion to the intact and abraded skin in rabbits and observed for 24 hours.Allyl butyrate was moderately irritating to rabbit skin after 24 hours of exposure.
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