Registration Dossier
Registration Dossier
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EC number: 219-307-8 | CAS number: 2408-20-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study in mouse for CAS no: 591-87-7
- Author:
- U.S .National library of medicine
- Year:
- 2 017
- Bibliographic source:
- ChemID plus A TOXNET DATABASE.2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of allyl acetate was performed in mouse.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Allyl acetate
- EC Number:
- 209-734-8
- EC Name:
- Allyl acetate
- Cas Number:
- 591-87-7
- Molecular formula:
- C5H8O2
- IUPAC Name:
- prop-2-en-1-yl acetate
- Details on test material:
- - Name of test material (as cited in study report):allyl acetate
- Molecular formula :C5H8O2
- Molecular weight :100.116g/mole
- Substance type:organic
- Physical state:No data available
--Purity:No data available
- Impurities (identity and concentrations):No data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):allyl acetate
- Molecular formula :C5H8O2
- Molecular weight :100.116g/mole
- Substance type:organic
- Physical state:No data available
--Purity:No data available
- Impurities (identity and concentrations):No data available
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 170mg/kg
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 170 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed
- Clinical signs:
- other: Clinical signs like behavioural somnolence (general depressed activity) was observed in treated mouse.
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- LD50 was considered to be 170mg/kg body weight. When mouse were treated with allyl acetate (591-87-7) orally.
- Executive summary:
Acute oral toxicity study was done in mouse usingallyl acetate(519-87-7).50% mortality was observed at dose 170mg/kg bw.Clinical signs like behavioural somnolence (general depressed activity) was observed in treated mouse. HenceLD50 was considered to be170mg/kgbody weight. When mouse were treated withallyl acetate (591-87-7) orally.
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