Registration Dossier
Registration Dossier
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EC number: 289-969-0 | CAS number: 90046-02-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Juniperus oxycedrus, Cupressaceae.
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Principle of test:
Male albino rats (25-30 g. n = 10) were treated with increasing doses of each extract (800, 1000, 1200, 1400 and 1600 mg/kg) according to the Reed & Muench (1938) method. The animals were kept under observation for a period of 24 hours and the number of deaths was recorded.
- Short description of test conditions: Treatment of the animals during the experiments was according to the Spanish criteria for the care and use of animals in experinientation published in the Boletin Oficial del Estado (B.O.E., n.º 250; 18-10-1989). - GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Juniper, Juniperus oxycedrus, ext.
- EC Number:
- 289-969-0
- EC Name:
- Juniper, Juniperus oxycedrus, ext.
- Cas Number:
- 90046-02-9
- IUPAC Name:
- Empyreumatic oil obtained from Juniperus oxycedrus (Cupressaceae) wood by dry distillation
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 25 - 30g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- physiological saline
- Doses:
- 800, 1000, 1200, 1400 and 1600 mg/kg
- No. of animals per sex per dose:
- 10 males per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 24 hours
- Necropsy performed: no/not specified. - Statistics:
- Reed & Muench (1938) cumulative method.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Conclusions:
- The acute intraperitoneal LD50 of the test item to rats was reported to exceed 3000 mg/kg.
- Executive summary:
Methanol and dichloromcthanol extracts of leaves and stems of Juniperus oxycedrus (Cupressaceae) were tested for their toxicity, analgesic. antiinflammatory and central effects. Both extracts showed low acute toxicity and decreased spontaneous motility. Both extracts showed a LD50 > 3000 mg/kg bw in mice and rats.
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