Registration Dossier
Registration Dossier
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EC number: 204-246-1 | CAS number: 118-33-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from RTECS and peer reviwed journal.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- TOXICITY AND ECOTOXICITY OF SULFONIC ACIDS: STRUCTURE-ACTIVITY RELATIONSHIP
- Author:
- GREIM H, J. AHLERS, R. BIASd, B. BROECKER, H. HOLLANDER, H.-P. GELBKE.H.-J. KLIMISCH, I. MANGELSDORF, A. PAETZ, N SCHGN, G. STROPP,R. VOGEL, C. WEBER, K. ZIEGLER-SKYLAKAKIS and E. BAYER
- Year:
- 1 994
- Bibliographic source:
- Chemophere. Vol. 28, No. 12, pp. 2203.2236, 1994
- Reference Type:
- secondary source
- Title:
- RTECS - QJ6125000
- Author:
- RTECS® is a United States trademark owned and licensed under authority of the U.S. Government
- Year:
- 1 997
- Bibliographic source:
- RTECS - QJ6125000, RTECS®, review date – September, 1997
- Reference Type:
- review article or handbook
- Title:
- Skin Irritation of 6-Amino-Naphthalene-1,3-Disulfonic Acid
- Author:
- Richard J Lewis, Sr
- Year:
- 2 012
- Bibliographic source:
- SAX's Dangerous properties of industrial material, 12th edition, 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Skin irritation test of test chemical 6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) was conducted on rabbit to examine the degree of skin irritancy caused by the chemical.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 6-aminonaphthalene-1,3-disulphonic acid
- EC Number:
- 204-246-1
- EC Name:
- 6-aminonaphthalene-1,3-disulphonic acid
- Cas Number:
- 118-33-2
- Molecular formula:
- C10H9NO6S2
- IUPAC Name:
- 6-aminonaphthalene-1,3-disulfonic acid
- Test material form:
- solid
- Details on test material:
- - Name of test material : 6-aminonaphthalene-1, 3-disulfonic acid
- Molecular formula : C10H9NO6S2
- Molecular weight : 303.314 g/mol
- Smiles notation : c12c(cc(S (=O)=O)cc1S (=O)=O )cc cc2
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 6-aminonaphthalene-1,3-disulfonic acid
- Common name: 6-Amino-1,3-naphthalenedisulfonate
- Molecular formula: C10H9NO6S2
- Molecular weight: 303.314 g/mol
- Smiles notation: c12c(cc(S(O)(=O)=O)cc1S(O)(=O)=O)cc(N)cc2
- InChl: 1S/C10H9NO6S2/c11-7-1-2-9-6(3-7)4-8(18(12,13)14)5-10(9)19(15,16)17/h1-5H,11H2,(H,12,13,14)(H,15,16,17)
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Amount / concentration applied:
- 2mg
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- No data available
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Severe skin irritating effects were observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test chemical 6-amino-1,3- Naphthalene disulfonic acid (CAS No: 118-33-2) was severely irritating to rabbits’ skin after 24 hours of exposure.
Hence, 6-amino-1,3- Naphthalene disulfonic acid(CAS No: 118-33-2) can be considered as skin irritant. - Executive summary:
Skin irritation test of test chemical 6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) was conducted on rabbit to examine the degree of skin irritancy caused by the chemical.
The rabbits were exposed to 2 mg of chemical dermally for 24 hours and later observed for skin reactions.
Since the chemical induce sever skin reactions,6-amino-1,3- Naphthalene disulfonic acid(CAS No: 118-33-2) was considered to be irritating to rabbits’ skin.
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