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EC number: 692-713-4
CAS number: 886588-62-1
Based on the legal requirements for Workers Safety according to current
German law (Gefahrstoffverordnung [Ordinance on Dangerous Substances],
15 November 1999), this study was designed to evaluate in rats the acute
toxicity of CD 713 TD subsequent to a single oral administration by
The study was performed following the revised version of OECD Guideline
423 (Acute Oral Toxicity - Acute Toxic Class Method, October 2000) and
in accordance with the principles of Good Laboratory Practice, as
described by the respective OECD Guidelines and current German law
(Chemikaliengesetz [Chemicals Act] 2002).
CD 713 TD was suspended in 0.5% aqueous hydroxyethylcellulose (Natrosol®
250 HX) and administered by oral gavage (10 mL/kg) at single doses of
200 mg/kg and 2000 mg/kg, respectively, to groups of three
CrlGlxBrlHan:WI rats, which were approximately 8 weeks old. Their body
weight ranged from 177 g to 195 g in males and from 131 g to 136 g in
The observation period post administration was 14 days. Clinical signs
were evaluated frequently on the day of administration (Day 1), as well
as once or twice daily thereafter. Body weight was recorded one day
before administration (Day -1), and, during the observation period, on
Day 1, 2, 8 and 15, respectively. At the end of the observation period,
necropsy was performed on all animals, and all gross macroscopical
changes were recorded.
No mortality occurred in both male and female rats.
Clinical observations were recorded on Day 1 only and comprised
piloerection (in both male and female rats from 0.25 h to 2.0 h post
administration) as well as reduced motor activity (in males 0.5 h post
administration only). All rats returned to normal on Day 1 (4.0 h post
No influence on body weight development and no gross macroscopic changes
at necropsy were observed.
All three females had to be sacrificed on Day 1 (about 0.5 h post
administration) due to poor general condition (characterized by
convulsions and lateral position) for reasons of animal welfare.
Piloerection (starting 0.25 h post administration) was the only clinical
sign observed earlier.
Alterations in the liver (stasis) and the small intestine
(discoloration, liquid luminal content) were observed at necropsy of all
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