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EC number: 692-713-4
CAS number: 886588-62-1
Based on current German law (Chemikaliengesetz [Chemicals Act] 2002),
this study was designed to evaluate the dermal tolerance of BI 1356/CD
713 TD subsequent to topical application in rabbits. It was performed
according to OECD Guideline 404 (Acute Dermal Irritation/Corrosion) and
in accordance with the principles of Good Laboratory Practice, as
described by the respective OECD Guidelines and current German law
A total of three female New Zealand White rabbits were exposed dermally
to a paste of approximately 0.5 g test item mixed with demineralized
water. One female was treated at three different sites for 3 min, 1 h,
and 4 h, respectively, whereas the remaining two females were exposed
for 4 h at a single site only. Skin reactions were recorded 1 h, as well
as 24 h, 48 h, and 72 h following the end of exposure and graded.
Further investigations included recording of clinical signs and body
Under the conditions of the present study, BI 1356/CD 713 TD was well
tolerated subsequent to topical application on rabbit skin. There were
no macroscopic signs of irritation or corrosion. In addition, there were
no signs of systemic side effects or of skin alterations beyond the area
of exposure. Thus, according to the Globally Harmonized Hazard
Classification and Labeling Scheme (GHS), the test item BI 1356/CD 713
TD is not classified.
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