Registration Dossier
Registration Dossier
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EC number: 943-336-1 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
FC-72 is not expected to be toxic to algae at the limit of solubility (84.1 µg/L) by readacross from category members FC-3284 and FC-770. No toxicity was observed to P. subcapitata in OECD201 assays tested at the limit of media solubility. These category member results are considered applicable to FC-72.
Key value for chemical safety assessment
Additional information
FC-72 is a member of the Perfluorinated Organic Chemicals, C5-C18 category. Because these substances exhibit similarity in their physicochemical properties and toxicological properties in mammals, and because available data indicates that parent molecules are not reactive toward biological molecules and cannot undergo bioactivation by normal enzymatic processes, they can be considered members of a chemical category. Data gaps for ecological toxicity can therefore be addressed by read-across and/or trend analysis between category members. No studies of toxicity to algae and cyanobacteria are available for FC-72. Reliable OECD201 studies are available for algae toxicity of category members perfluoromethyl morpholine (FC-3284), and FC-770. In both cases, EC50s (72-h and 48-h, respectively) were in excess of the maximum achievable test substance concentrations. Analytically determined test substance concentrations are not reasonable to use for readacross since the solubilities of FC-3284 and FC-770 are substantially higher than that of FC-72. Lack of toxicity at the limit of solubility is read across qualitatively to FC-72. The solubility limit of FC-72 in pure water was determined to be 84.1 µg/L. Therefore, 84.1 µg/L is accepted as the basis for estimating the highest possible exposure concentration of FC-72 in order to define the EC50 and NOEC.
Please see IUCLID section 13 for a matrix of aquatic toxicity data for members of the Perfluorinated Organic Chemicals C5-C18 category.
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