2,5-dihydroxy-3,6-dimethyl-3,6-bis(dihydroxyphosphinyl)-1,4,2,5-dioxadiphosphorane-2,5-dioxide

Additional physico-chemical information

Administrative data

Endpoint:

other: self-reactive properties

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

2015-11-10 to 2015-12-07

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Study conducted according to OECD guideline and under GLP. Technical limitations (Klimisch score 2 for the test substance), but sufficient for purpose. Test substance adequately specified. Maximum reliability score of 2 for use as a read-across. Justified based on structural similarity and manufactured composition.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2016

Report date:

2016

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: UN MTC App.6 (screening procedure) and sub-section 20.3.3.3.

Deviations:

yes

Remarks:

(end temperature)

Principles of method if other than guideline:

Differential scanning calorimetry

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

(2,5-dihydroxy-3,6-dimethyl1-1,4,2,5-dioxadiphosphorinane- 3,6-diyl)bisphosphonic acid- P,P'-dioxide, hexasodium salt

Cas Number:

34452-69-2

IUPAC Name:

(2,5-dihydroxy-3,6-dimethyl1-1,4,2,5-dioxadiphosphorinane- 3,6-diyl)bisphosphonic acid- P,P'-dioxide, hexasodium salt

Constituent 2

Reference substance name:

2,5-dihydroxy-3,6-dimethyl-3,6-bis(dihydroxyphosphinyl)-1,4,2,5-dioxadiphosphorinane-2,5-dioxide, hexasodium salt

IUPAC Name:

2,5-dihydroxy-3,6-dimethyl-3,6-bis(dihydroxyphosphinyl)-1,4,2,5-dioxadiphosphorinane-2,5-dioxide, hexasodium salt

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

- Name of test material (as cited in study report): ADPA Dimer Na Salt (wet cake)
- Physical state: White crystalline solid
- Storage condition of test material: At room temperature, in the original plastic, opaque, container

Results and discussion

Results:

With both experiments, no exothermic decomposition effects were observed.
After the experiments, a white residue remained at the bottom of the sample container. The sample container was expanded due to pressure.

Any other information on results incl. tables

DSC-curves obtained are provided in the experimental report.

Applicant's summary and conclusion

Conclusions:

(from analogue) The dossier substance is not anticipated to exhibit self-reactive properties, according to CLP criteria. No further testing required.

Executive summary:

Self-reactive properties of the test item, was determined according to UN guideline, DSC method, under GLP. The substance was tested as supplied.

The lack of exothermal decomposition up to 300°C was considered to be a safe indication that the estimated SADT of the test item is greater than 75°C.

Read-across is justified for the analogue, based on similar chemical structure, lower content, liquid form (aqueous) and lack of exothermal effect with the test substance, suggesting margin of safety sufficient for classification purpose.