Registration Dossier
Registration Dossier
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EC number: 292-771-7 | CAS number: 90990-10-6
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No toxicity is expected for microorganisms.
Key value for chemical safety assessment
Additional information
Within the fatty acid category studies describing the toxicity of fatty acids to Pseudomonas putida are available. For the mixture under discussion three studies were used as read-across from C8, C12 and C14 fatty acids.
For the octanoic acid C8 (CAS 124 -07 -2) a cell multiplication inhibition test was conducted following GLP-requirements. The used method in the tests was similar to the ISO guideline 10712. In the study an EC10 (18 h) of 912 mg/L (nominal) was reported (Coenen, 1988).
In addition tests was conducted with lauric acid C12 (CAS 143 -07 -7) and myristic acid C14 (544 -63 -5) on Pseudomonas putida according to DIN 38472 Part 27 (Geisel and Berger, 1998 and Kirch 1994). In these test EC10 of >1000 mg/L were reported after 30 min exposure based on respiration rate for all tested substances. Though these tests do not meet the requirements of todays standard procedures the results are considered reliable to demonstrate the low toxicity of the test substance to microorganisms.
The available tests for the pure homologues were used for a weight of evidence approach for the fatty acid mixture under consideration.
Concluding from the available results, fatty acids are regarded as non-toxic to microorganims. For the PNEC-calculation the EC10 -value of 912 mg/L was used.
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