Registration Dossier
Registration Dossier
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EC number: 203-786-5 | CAS number: 110-63-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
1,4 -Butanediol was not sensitising when applied to male and female guinea pigs in a non-GLP, non-guideline study performed according to the methods described by Magnusson and Kligman (Jedrychowski, 1990). Given these results, 1,4 -Butanediol is not expected to cause skin sensitisation.
Migrated from Short description of key information:
Not sensitising
Respiratory sensitisation
Endpoint conclusion
- Additional information:
Not expected to be a respiratory sensitiser based on substantial human experience and absense of skin sensitisation.
Migrated from Short description of key information:
Not expected to be a respiratory sensitiser.
Justification for classification or non-classification
Based on the results of a Guinea Pig Maximisation test 1,4-butanediol is judged not to be a skin sensitizer under the EU CLP criteria (EU Regulation 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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