Registration Dossier
Registration Dossier
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EC number: 939-265-0 | CAS number: 90583-18-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Reference Type:
- secondary source
- Title:
- SIDS Category of Alkyl sulfates, Alkane sulfonates and Alpha-olefin sulfonates
- Author:
- OECD
- Year:
- 2 007
- Bibliographic source:
- UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- The study was performed under occlusive conditions. No data on vehicle availabe.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 90583-18-9 (purity 40.9-42%)
- IUPAC Name:
- 90583-18-9 (purity 40.9-42%)
- Details on test material:
- - Name of test material (as cited in study report): trade name
- Physical state: No data
- Analytical purity: 40.9-42% a.i.
- Lot/batch No.: No data
- Storage condition of test material: No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Kleinrusse Chbb:HM
Test system
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Controls:
- not required
- Amount / concentration applied:
- Concentration: 25% a.i.
Amount applied: 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 21 days
- Number of animals:
- 5
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: mean of all 5 animals
- Time point:
- 24/48/72 h
- Score:
- 3.7
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- other: mean of all 5 animals
- Time point:
- 24/48/72 h
- Score:
- 2.1
- Max. score:
- 4
- Reversibility:
- fully reversible
Any other information on results incl. tables
time (hrs) time (days)
1 24 48 72 7 10 14
mean E 1.8 3.6 3.8 3.6 2.8 1.8 0
mean O 0 1.8 2.4 2.2 1.8 1.4 0
E = erythema
O = oedema
Reversibility: yes
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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