Glycerol, propoxylated, esters with acrylic acid

Hydrolysis

Description of key information

In a study according to OECD test guideline 111 under GLP, the test substance was slightly hydrolytically instable with a half life of 253 days at 20°C and pH 7. Adjusting to an average EU outdoor temperature of 12°C, the half-life was calculated to be 512 days at pH 7 (mean half-life from three temperatures).

Key value for chemical safety assessment

Half-life for hydrolysis:

512 d

at the temperature of:

12 °C

Additional information

The hydrolysis of the test substance as a function of pH was determined according to OECD Guideline No. 111.

The definitive testing was conducted with a test item concentration of 8 mg/L in buffer solutions of pH 7 and 9 at temperatures of 20, 30 and 50 °C, respectively. Samples were taken at test start (0 h) and at least 8 spaced points between test start and end. Buffer solutions did not analytical interference with the test substance. Analyses of the test substance were performed via LC-MS on a reversed phase column for the for main components with a validated method.

The test substance was slightly hydrolytically instable at pH 7, 20 °C (half-life: 253 days) and 30 °C (half-life: 132 days)

and hydrolytically instable at pH 7, 50°C (half-life: 23.9 days) and pH 9 (half-life: 12 to 0.35 days), with increasing instability to higher pH and higher temperature.

The slope of the regression graphs for the pH 7, 20 and 30°C test conditions was not significantly different from zero, thus these results should be treated with respect to the high uncertainty of the evaluated data.

Adjusting to an average EU outdoor temperature of 12°C, the half-life was calculated to be 515 days at pH 7 (mean half-life from three temperatures) according to Chapter R.16: Environmental Exposure Estimation of the Guidance on information requirements and chemical safety assessment (Equation R.16 -15).