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EC number: 237-159-2
CAS number: 13674-87-8
In the atmosphere a half-life of 21.3 h for TDCP is estimated due to
indirect photolysis with hydroxyl radical.
A study revealed that reaction with oxidative species such as ozone or
hydroxyl radicals can proceed rapidly, but the paper did not relate the
data to typical environmental conditions.
A hydrolysis study revealed that the rate of hydrolysis at
environmentally-relevant pH values is fast enough to have any influence
on predicted environmental concentrations. The most rapid t1/2 at pH 9 :
> 120d at 20 °C.
TDCP has been shown to be not readily biodegradable in water. No
definitive conclusion can be reached regarding inherently
biodegradability or biodegradation under anaerobic conditions.
In soil very little degradation (< 6%) occured in a 17 -week study.
The measured BCF of 45 l/kg is used in the risk assessment; this is the
arithmetic mean of the range 31 to 59 l/kg. Since the values are in a
narrow range, a mean is considered acceptable and representative.
The measured BCF for TDCP is relatively low in comparison with the
predictions and with other substances of similar log Kow values. There
could be various causes for such a result, including the observed rapid
metabolism in the organism.
For TDCP, good agreement is found between the QSAR predictions of Kocfrom
Kow(Koc= 950.8 (range 633.4 – 1427.2) and the
value measured in the OECD 106 study (Koc= 1780 (range 1540 –
2010). The HPLC screening estimates of Kocappear to
consistently over-estimate this value for the chloroalkylphosphates. For
TDCP, the Kocmeasured in the OECD 106 study will be used for
the risk assessment, Koc= 1780 log Koc= 3.25.
Henry's law constant
A Henry’s Law constant of 1.24 x 10-4 Pa.m3/mol can be calculated
from the vapour pressure and water solubility. This indicates a
preference for water compared to air, and hence a low rate of
volatilisation from surface water to air.
The persistence criteria currently laid down in the TGD require a
half-life >60 days in marine water (or >40 days in fresh water) or >180
days in marine sediment (or >120 days in freshwater sediment). The
available screening studies show that TDCP is not readily biodegradable
so the screening criterion for persistence is met.
The criterion used in the TGD for
bioaccumulation is a bioconcentration factor (BCF) >2,000 l/kg. TDCP has
a measured fish BCF of 31-59 in the only acceptable result of three
studies and hence does not meet the B criterion.
The toxicity criterion used in the TGD is a chronic NOEC
<0.01 mg/l or substances classified as Carcinogenic (category 1 & 2),
Mutagenic (category 1 & 2), or Toxic to Reproduction (category 1,2, & 3)
or with other evidence of chronic toxicity. The lowest aquatic NOEC for
TDCP is 2 µg/L from a 6 month development and growth study with the fish Danio
rerio. Regarding human health effects, TDCP is classified as
Carcinogenic (re-evaluation of existing data as reported in Faust and
Meehan, 2011). Based on the current evidence, combined with the aquatic
toxicity results, there is clear evidence of chronic toxicity and hence
the T criterion has been met.
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