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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
unsuitable test system

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Principles of method if other than guideline:
The test was performed in principle as described in OECD test guideline 403. It demonstrates the toxicity of a dusty atmosphere generated by blowing 200 L/h air through a 5 cm layer of the dusty test substance in a glass cylinder for 7 hours. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during exposure, and the amount of air used during exposure. Group-wise documentation of clinical signs was performed over a 7 day study period. Body weight of groups was determined before the start of the study and at the end of the observation period.
GLP compliance:
no
Test type:
other: Inhalation Risk Test

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium methanolate
EC Number:
204-699-5
EC Name:
Sodium methanolate
Cas Number:
124-41-4
Molecular formula:
CH4O.Na
IUPAC Name:
sodium methanolate

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
no information given

ENVIRONMENTAL CONDITIONS
no information given

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
no information given
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
7 h
Concentrations:
1.7071 mg/L (calculated)
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology
Statistics:
no information given

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 1.707 mg/L air (nominal)
Exp. duration:
7 h
Mortality:
all 12 animals survived the 7 hours of exposure
Clinical signs:
other: none reported
Body weight:
no information given
Gross pathology:
no abnormal findings reported

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
No mortalities occurred after a 7-h exposure to 1.7071 mg/L by inhalation. Therefore, the LC50 value was > 1.7071 mg/L.