Registration Dossier
Registration Dossier
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EC number: 204-699-5 | CAS number: 124-41-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38412 part 12
- GLP compliance:
- no
- Analytical monitoring:
- no
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Limit test:
- no
- Total exposure duration:
- 24 h
- Duration:
- 24 h
- Dose descriptor:
- EC10
- Effect conc.:
- 24.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Assimilation inibition; inhibition of oxygen liberation
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 302.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Assimilation inibition; inhibition of oxygen liberation
- Duration:
- 24 h
- Dose descriptor:
- EC90
- Effect conc.:
- 3 800 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Assimilation inibition; inhibition of oxygen liberation
- Reported statistics and error estimates:
- Probit analysis
Reference
Description of key information
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 22 000 mg/L
Additional information
In water, sodium methanolate rapidly hydrolyses to methanol and sodium hydroxide (OECD, 2002). Due to the rapid hydrolysis of sodium methanolate, the assessment of the aquatic toxicity is based on the products of hydrolysis i.e. methanol and sodium hydroxide.
One toxicity study on algae is available for sodium methanolate. The toxicity of sodium methanolate to Scenedesmus subspicatus was tested according to DIN 38412 part 12 (no GLP, no analytical monitoring; Study director, 1989). Since the available data were insufficient for assessment, the study was classified as not assignable according to the Klimisch code. The test duration is not in line with today’s standard methods. Sodium methanolate revealed an EC50 (24 h) of 302.2 mg/L for the assimilation inhibition for the species Scenedesmus subspicatus supporting the overall low toxicity of the substance and its degradation products. Since the study is not assignable, the assessment is based on the degradation products of sodium methanolate only.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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