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Diss Factsheets
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EC number: 200-824-2 | CAS number: 74-95-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Several publications and the review by US EPA Health and Environmental Profile for Methylene Bromide (1987).
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Dibromomethane appears to be absorbed after oral and inhalation exposure in rats and rabbits (concluded based Repeated dose toxicity section) and after dermal exposure(Rodkey and Colloson 1977; McDougal etal., 1985). Dibromomethane was metabolized in vitro to carbon monoxide and inorganic bromide by microsomal enzymes of the liver, lungs, and kidney, but not of the brain or spleen (Kubic and Andreas 1975). The oxidation appears to be catalysed by a cytochrome P-450 dependent system (Kubic and Andreas 1975, 1978, Stevenes et al., 1980). During dermal exposure, the metabolism of dibromomethane was saturable as indicated by the nonlinear increase in plasma bromide ion concentration (McDougal et al., 1985). Intraperitoneal administration of 522 mg/kg dibromomethane to male rats resulted in a peak of carboxyhemoglobin level of 14% of the hemoglobi concentration at 4 hours treatment (Kubic and Andreas 1974). By 10 hours after treatment, the carboxyhemoglobin level was approaching the pre-treatment level. Repeated daily exposure did not result in accumulation of carboxyhemoglobin. The only information regarding the excretion of dibromomethane is that the metabolite carbon monoxide is excreted in the exhaled air (Rodkey and Collison 1977).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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