Registration Dossier
Registration Dossier
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EC number: 700-182-8 | CAS number: 134652-60-1
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 May to 28th May 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Recent study conducted by a GLP certified laboratory in accordance with a suitable study guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Remarks:
- This method was chosen as the expected water solubility was less than 10-2 g/l.
Test material
- Reference substance name:
- Tripropan-2-ylsilyl 2-methylprop-2-enoate
- EC Number:
- 700-182-8
- Cas Number:
- 134652-60-1
- Molecular formula:
- C13 H26 O2 Si
- IUPAC Name:
- Tripropan-2-ylsilyl 2-methylprop-2-enoate
- Details on test material:
- - Name of test material: TIS-M
- Lot/batch No.: 9925
- Expiration date of the lot/batch: 2 December 2010
- Storage condition of test material: Under nitrogen at room temperature, continuously protected from all light.
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- < 0 g/L
- Temp.:
- 20 °C
- pH:
- >= 7.23 - <= 7.25
- Details on results:
- Samples were directly injected and analysed with the above HPLC method.
Measured concentrations of TIS-M were below the quantification limit, 0.2 μg/ml
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility was determined to be less than 2 x 10-4 g/l at 20 °C ± 1°C. - Executive summary:
The water solubility of the registered substance was assessed according to EC A.6 using a Column elution HPLC method. It was calibrated using the following concentrations of calibration samples: 0.2, 0.5, 1, 2, 5 and 10 μg/ml. The water solubility of TIS-M was determined to be less than 2 x 10-4 g/l.
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