Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 252-161-3 | CAS number: 34708-08-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- experimental study planned
- Study period:
- After approval by ECHA
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 222 (Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei))
- Principles of method if other than guideline:
- The study is to be conducted with the hydrolysis product of the registered substance, in view of its hydrolysis rate - see IUCLID Section 6.3 for further details of the risk assessment approach. A tiered testing approach is proposed with the OECD 222, 216 and 211 studies to be conducted first in order to establish whether an OECD TG 208 plant test is required, based on the results of the screening approach.
Reference
Description of key information
OECD TG 222 Test Proposal
Key value for chemical safety assessment
Additional information
In the context of the Integrated Testing Strategy for the terrestrial compartment (ECHA guidance Chapter R.7c, terrestrial hazard classification scheme, Table R.7.11—2) (ECHA 2017) the substance is assigned to the soil Hazard Category 3 (see IUCLID Section 6.3 and CSR Section 7.2 for further details).
In this situation, a screening approach is applied, where the equilibrium partitioning risk assessment approach with an extra factor of ten, in addition to a confirmatory long-term terrestrial test, are to be conducted:
PEC/PNECscreen:
The PEC × 10 / PNECscreen based on the equilibrium partitioning method indicates the substance will have a risk characterisation ratio (RCR) >1. The highest terrestrial RCR is 8.48 in agricultural soil.
Confirmatory long-term test:
An OECD 222 study with earthworms is proposed with the hydrolsis product of the registered substance.
In addition, ECHA guidance Chapter R.7c, Table R.7.11—2 states the following: "If PEC/PNECscreen > 1 or indication of risk from confirmatory long-term soil toxicity test: Conduct long-term toxicity tests according to the standard information requirements Annex IX or X (invertebrates and plants), choose lowest value for derivation of PNECsoil". The PEC/PNECscreen is >1, which indicates that standard information requirements according to Annex IX or X should be conducted. However, a long-term aquatic toxicity study with invertebrates OECD 211 is proposed, which is likely to affect the PEC/PNECscreen. Therefore, it is proposed to review the results of the screening assessment once the OECD 211 and 222 study results are available, before concluding on the need to conduct the OECD 208 plant study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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