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EC number: 252-161-3
CAS number: 34708-08-2
The EC50 values determined for effects on growth rate are above the
highest test concentrations.
Table 1. Test results - test media prepared by direct dispersion
Table 2. Test results - test media prepared using TBA as solvent
Table 3. Test results - test media prepared using DMSO as solvent
h): 160 mg/l (nominal) and NOErC (96 h): 32 mg/l, based on
growth rate of Desmodesmus subspicatus (OECD Guideline 201).
A 96-hour ErC50
value of 160 mg/l and NOErC value of 32 mg/l (nominal) have
been determined for the effects of the registered substance, triethoxy(3-thiocyanatopropyl)silane
(CAS 34708-08-2; EC No. 252-161-3), on growth rate of Desmodesmus
subspicatus (reported as Scenedesmus subspicatus) (TNO,
The value was obtained by
extrapolation to above the highest test concentration from results
obtained in test media prepared by direct dispersion of the test
substance. The use of other methods of test media preparation did not
have a significant effect on the test result. A NOEC of 32 mg/l has been
estimated from the test results.
In a separate study,
conducted by the same laboratory, a 72-hour ErC50 value
of >10 mg/l and NOErC value of ≥10 mg/l have been
determined for the effects of the test substance on growth rate and of Desmodesmus
subspicatus (TNO, 1992b).
The test solutions were
prepared using tert-butyl alcohol (TBA) (TNO, 1992a and b) and dimethyl
sulfoxide (DMSO) (TNO 1992a only) as solvents. The recommended solvent
concentration (100 mg/l) was not exceeded during the test, and it is
therefore unlikely that TBA or DMSO significantly affected the results
of the test.
In addition, the test
substance is susceptible to hydrolysis and it is likely that the test
organisms were exposed to a mixture of the parent compound and the
hydrolysis products of the substance in both tests.
Above a concentration of
approximately 1000 mg/l, dimeric/oligomeric, cyclic or cross-linked
condensation products could potentially form over time in the aqueous
test media. There was no report of undissolved material (parent
substance or precipitated by products) indicated in the study report for
A functional group
associated with ecotoxicity by a specific mode of action (thiocyanate)
is present in both the registration substance and the silanol hydrolysis
product, and the effects seen are attributed to this. It is therefore
reasonable to conclude that both the parent and hydrolysis product could
contribute to any effects observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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