Registration Dossier
Registration Dossier
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EC number: 201-696-0 | CAS number: 86-74-8
Carcinogenicity
Administrative data
Description of key information
Carbazole caused neoplastic lesions in the livers of B6C3F1 mice under test conditions. Tumors were also noticed in the forestomach but at lower incidence and prevalently at the higher doses. A clear dose dependence of tumor incidence could not be observed.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 200 mg/kg bw/day
Justification for classification or non-classification
see IARC evaluation: not classifiable
Additional information
Overall evaluation of IARC 1999, Vol 71, p. 1319:
Carbazole is not classifiable as to its carcinogenicity to humans (Group 3).
No epidemiological data relevant to the carcinogenicity of carbazole were available.
There is limited evidence in experimental animals for the carcinogenicity of carbazole.
Carcinogenicity: via oral route (target organ): digestive: liver; digestive: other
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