Registration Dossier
Registration Dossier
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EC number: 201-696-0 | CAS number: 86-74-8
Endpoint summary
Administrative data
Description of key information
Additional information
Biodegradation in water: screening tests
In two tests for ready biodegradability, contradictory results were obtained using carbazole as test substance.
NITE/CERI 2002/1999 reports no biodegradation of carbazole after 2 weeks in a MITI I test.
In a biodegradation test according to OECD test guideline 301 E, 86% biodegradation was observed within 7 days (Knacker/UBA 1989). The pass levels for ready biodegradability were met.
Causes of these inconsistent findings on biodegradation are not obvious. However, based on the findings that even adapted bacteria are limited in their capacity to degrade carbazole (see below), the result of ready biodegradability (Knacker/UBA 1989) seems to be erroneous and is considered to be invalid.
Biodegradation in water and sediment: simulation tests
Adapted bacteria are able to biodegrade carbazole to some degree.
In a primary biodegradation test using adapted microorganism prepared from creosote contaminated soil by extraction in phosphate buffer, 58.6 and 65.5% degradation were observed after 3 and 14 days respectively (Mueller 1991).
23.6% of the applied radioactivity (14C labeled carbazole) was determined as radiolabeled CO2 in a biodegradation test using a bacterial population as inoculums which was grown on crude oil as sole carbon source for some years and crude oil as sole substrate amended with a minimal amount of 14C labeled carbazole (Foght 1989).
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