3-chloroaniline

Endpoint summary

Additional information

Toxicity to soil macroorganisms except arthropods

No. of studies were reviewed for toxicity to soil macroorganisms except arthropods from reliable sources having Klimisch rating 2 and 4.

The summary of the results are presented below  

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Sources
1	LC50	169.22 mg/kg soil dw	Mortality	48 hrs	Allolobophora tuberculata	Predicted data from QSAR for CAS : 108-42-9
2	EC50	90-270 mg/kg soil dw	Reproduction	56 days	Eisenia fetida	Experimental data from J. Soils Sediments for RA CAS : 95-76-1

 

Based on the studies summarized in the above table for the target substance 3-chloroaniline and the read across substance 3,4-dichloroaniline in a soil macroorganisms (Allolobophora tuberculata and Eisenia fetida),the endpoint value was found to vary between the lethal concentration (LC50) = 169.22 mg/kg soil dw and effective concentration (EC50) = 90-270 mg/kg soil dw in a 48 hrs study to 21 days study on the basis of mortality and reproduction effect.

Toxicity to terrestrial arthropods

No. of studies were reviewed for toxicity to terrestrial arthropods from reliable sources having Klimisch rating 2 and 4.

The summary of the results are presented below  

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Sources
1	LD50	82.625 µg per animal	Mortality	48 hrs	Apis mellifera	Predicted data from QSAR for CAS :108-42-9
2	EC50	10 -30 mg/kg soil dw	Reproduction	28 days	Folsomia candida	Experimental data from J. Soils Sediments for RA CAS : 95-76-1

 

Based on the studies summarized in the above table for the target substance 3-chloroaniline and the read across substance 3,4-dichloroaniline in terrestrial arthropods (Apis mellifera and Folsomia candida),the endpoint value was found to vary between the lethal dose (LD50) = 82.625 µg per animal and effective concentration (EC50) = 10 -30 mg/kg soil dw in a 48 hrs study to 28 days study on the basis of mortality and reproduction effect.

Toxicity to terrestrial plants

No. of studies were reviewed for toxicity to terrestrial plants from reliable sources having Klimisch rating 2 and 4.

The summary of the results are presented below  

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Sources
1	NOEC	32 mg/kg	Mortality	14 days	Lactuca sativa	Experimental data from TNO-Rapport No.21003 for CAS : 108-42-9
2	EC50	15 mg/kg	Mortality	14 days	Lactuca sativa	Experimental data from TNO-Rapport No.21003 for CAS : 108-42-9
3	EC50	15 mg/kg soil	Population	14 days	Lactuca sativa	Experimental data from Environ. Toxicol. Chem.for CAS : 108-42-9

 

Based on the studies summarized in the above table for the target substance 3-chloroaniline in terrestrial plants (Lactuca sativa),the endpoint value was found to vary between the effective concentration (EC50) = 15 mg/kg and no observed effect concentration (NOEC) = 32 mg/kg in

a 14 days study on the basis of mortality and population effect.

Toxicity to soil microorganisms

Since

a) 3-chloroaniline is readily biodegradable and is mineralised rapidly to CO2 in aerobic systems,

b)3-chloroaniline is not applied directly to soil and

c) 3-chloroaniline is not expected to be transferred indirectly to soil in significant quantity via disposal of STP sludges or aerial deposition, exposure of soil micro organisms to 3-chloroaniline is unlikely to occur.

Consequently tests of the toxicity of 3-chloroaniline to soil micro organisms are considered to be unnecessary.

Toxicity to birds

No information on toxicity to birds available. Toxicity to birds is not a standard information requirement in Annex IX. Moreover, as the substance is not toxic to mammals (not classified for toxicity) no further toxicity testing on birds is proposed.

Toxicity to other above-ground organisms

No experimental data in addition to those presented under CSR Chapter 5 is available. This is not a standard information requirement for environment in REACH.