3-chloroaniline

Toxicity to aquatic algae and cyanobacteria

Description of key information

The effective concentration (EC50) value of 3-chloroaniline in aquatic green algae (Chlorella pyrenoidosa) in a 96 hr study on the basis of growth rate effect was found to be 21 mg/L. But the BCF value of 3-chloroaniline reported was not >= 500 as well as the substance was found to be rapidly degradable.Thus considering only the value from CLP Criteria for aquatic classification of the substance , it is concluded that 3-chloroaniline exhibits toxicity to aquatic algae (Chlorella pyrenoidosa) in category 3.

Key value for chemical safety assessment

EC50 for freshwater algae:

21 mg/L

Additional information

No. of studies were reviewed for toxicity to aquatic algae and cyanobacteria from reliable sources having Klimisch rating 2 and 4.

The summary of the results are presented below  

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Sources
1	EC50	21 mg/L	Growth rate	96 hrs.	Chlorella pyrenoidosa	Experimental data  for CAS : 108-42-9
2	EC50	53 mg/L	Population	48 hrs.	Scenedesmus subspicatus (new name: Desmodesmus subspicatus)	Experimental data from Water Research for CAS : 108-42-9
3	EC50	26 mg/L	Population	48 hrs.	Scenedesmus subspicatus (new name: Desmodesmus subspicatus)	Experimental data from Water Research for CAS : 108-42-9
4	EC50	0.74 mg/L	Population	96 hrs.	Pseudokirchnerella subcapitata	Experimental data from study report for RA CAS : 95-76-1

 

Based on the studies summarized in the above table for the target substance 3-chloroaniline and the read across substance,the endpoint value was found to vary between EC50 = 0.74 mg/L to 53 mg/L in a 48 hrs. to 96 hrs. study on the basis of growth rate and population effect. Based on the EC50 values ranging from 21 mg/L to 53 mg/L,the substance qualify for the aquatic classification in Category 3.But EC50 value of read across substance was found to be 0.74 mg/L which exhibits toxicity in aquatic Acute Category 1.