Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 282-823-7 | CAS number: 84434-23-1
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
On the basis that the results from the test material used in the acute oral toxicity study in rats, 3-(4-tert-butylphenyl)propionaldehyde used to the support the registration of 3-(4-tert-butylphenyl)acrylaldehyde using a read-across approach, 3-(4-tert-butylphenyl)acrylaldehyde should therefore also be considered as not acutely toxic by the oral route. In accordance with Regulation 1272/2008 and Directive 67/548/EEC, the substance does not meet the classification criteria for acute toxicity by the oral route.
On the basis that the results from the test material used in the in vivo skin irritation study in rabbits and the validated in vitro study (reconstructed human epidermis model), 3-(4-tert-butylphenyl)propionaldehyde, used to support the registration of 3-(4-tert-butylphenyl)acrylaldehyde using a read-across approach, 3-(4-tert-butylphenyl)acrylaldehyde should therefore
also be considered as a skin irritant. In accordance with Regulation 1272/2008 and Directive 67/548/EEC, the substance should be classified as H315 Causes skin irritation (Category 2) with the signal word 'Warning' and Xi R38 Irritating to skin, respectively.
On the basis that the results from the test material used in the skin sensitisation study (Mouse LLNA), 3-(4-tert-butylphenyl)propionaldehyde, are being used to the support the registration of 3-(4-tert-butylphenyl)acrylaldehyde using a read-across approach, 3-(4-tert-butylphenyl)acrylaldehyde should therefore also be considered to be sensitising to the skin.
In accordance with Regulation 1272/2008 and Directive 67/548/EEC, the substance should be classified as H317 May cause an allergic skin reaction (Subcategory 1B) with the signal word 'Warning' and Xi R43 May cause sensitisation by skin contact, respectively.
On the basis that the results from the reverse gene mutation study in bacteria performed with 3-(4-tert-butylphenyl)propionaldehyde, are being used to the support the registration of 3-(4-tert-butylphenyl)acrylaldehyde using a read-across approach, 3-(4-tert-butylphenyl)acrylaldehyde should therefore also be considered as not mutagenic in the reverse gene mutation assay in bacteria. The available information is not sufficient to determine the classification of the substance in accordance with Regulation 1272/2008 and Directive 67/548/EEC, for genetic toxicity as the available information does not include an evaluation of the cytogenicity of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
