Registration Dossier
Registration Dossier
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EC number: 219-847-4 | CAS number: 2550-26-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitisation key study
The result from a fully reliable study (Bernard 2012) conducted according to OECD TG 429 using 25 %, 50 % and 100 % of the test item shows that 4-phenylbutan-2-one has no sensitising potential.
Supporting information
In a patch-test with humans (Ishihara 1978) it was shown that there was no pre-existing skin sensitisation to 4-phenylbutan-2-one in dermatologic patients.
Migrated from Short description of key information:
4-phenylbutan-2-one does not show an allergenic potential when tested up to the concentration of 100%.
Justification for selection of skin sensitisation endpoint:
GLP study according to OECD TG 429 (Skin sensitisation: Local Lymph Node Assay).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Migrated from Short description of key information:
not required
Justification for classification or non-classification
- skin sensitisation:
Based on the above stated assessment of the skin sensitisation potential, 4-phenylbutan-2-one does not need to be classified according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) or according to CLP (Regulation (EC) No 1272/2008 of the European Parliament and of the Council) as implementation of UN-GHS in the EU.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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