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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
12 September 2014 to 23 March 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose for cross-reference:
reference to other study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
0.566 g/L
Conc. based on:
test mat.
Remarks:
component 1
Loading of aqueous phase:
1 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
>= 6.5 - <= 6.9
Remarks on result:
other: monomer component
Water solubility:
< 0 g/L
Conc. based on:
test mat.
Remarks:
component 2
Loading of aqueous phase:
1 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
>= 6.5 - <= 6.9
Remarks on result:
other: main dimer component
Details on results:
PRELIMINARY TEST
- The preliminary estimate of the water solubility at 20.0 ± 5 °C was 0.160 g/L (component 1) and ≤ 3.6 x 10E-05 g/L (component 2).
- The solution was determined to have a pH of 7.3

DEFINITIVE TEST
- Typical chromatograms are attached.
- The main peak areas for the standard solutions are shown in Table 3.9 (attached).
- The main peak areas for the sample solutions are shown in Table 3.10 (attached).
- Concentration (g/L) of test item in the sample solutions is shown in Table 3.11 (below).

VALIDATION
- The linear relationship of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 10 mg/L for component 1, component 2 and for all peaks within the chromatography.
- Satisfactory responses were obtained with a correlation coefficient (r2) of 1.000
- The concentration was for the test item as a whole and was not corrected for percentage composition of components 1 and 2.

TABLE 3.11 – CONCENTRATION OF TEST ITEM IN SAMPLE SOLUTIONS

Sample number

Time shaken at approximately 30 °C (hours)

Time equilibrated at 20 °C (hours)

Concentration component 1 (g/L)

Concentration component 2 (g/L)

Solution pH

1

24

24

0.161

None detected

6.5

2

48

24

0.215

6.86 x 10-4

6.7

3

72

24

0.132

None detected

6.9

4

48

24

0.114

None detected

6.5

Overall concentration for component 1 (see discussion) = 0.566 g/L at 20.0 ± 0.5 °C

Overall concentration for component 2 (see discussion) = < 1 x 1E-04 g/L at 20.0 ± 0.5 °C

Conclusions:
The water solubility of the test item was determined to be 0.566 g/L (monomer) and < 1 x 10E-04 g/L (dimers) at 20.0 ± 0.5 °C..
Executive summary:

GUIDELINE

The determination was carried by the flask method using a procedure designed to be compatible with Method A.6 Water Solutbility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

The water solubility of the test item was determined to be 0.566 g/L (monomer) and < 1 x 10E-04 g/L (dimers) at 20.0 ± 0.5 °C..

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
24 February 2015 to 20 March 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
0.566 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
2.5 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
>= 8 - <= 9.4
Details on results:
PRELIMINARY TEST
- The preliminary estimate of the water solubility was 0.631 g/L at 20.0 ± 5 °C and pH 7.7

MAIN TEST
- Typical chromatograms are attached.
- The main peak areas for the standard and sample solutions are shown in Table 3.2 (attached).
- Concentration (g/L) of test item in the sample solutions is shown in Table 3.3 (below).

VALIDATION
- The linearity of the detector response was assessed with respect to concentration over the nominal concentration range of 10 to 50 mg/L.
- Satisfactory results were obtained with a correlation coefficient (r2) of 0.998.

TABLE 3.3 – CONCENTRATION OF TEST ITEM IN SAMPLE SOLUTIONS

Sample number

Time shaken at approximately 30 °C (hours)

Time equilibrated at 20 °C (hours)

Concentration (g/L)

Solution pH

1

24

24

0.580

8.0

2

48

24

0.557

8.1

3

72

24

0.562

9.4

Mean concentration = 0.566 g/L at 20.0 ± 0.5 °C

Range = 0.557 to 0.580 g/L

Conclusions:
The water solubility of the test item monomer component was determined to be 0.566 g/L (monomer) at 20.0 ± 0.5 °C.
Executive summary:

GUIDELINE

The determination was carried by the flask method using a procedure designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

The water solubility of the test item monomer component was determined to be 0.566 g/L (monomer) at 20.0 ± 0.5 °C.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
11 October 2010 and 20 December 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
< 0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
0.2 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
30 °C
pH:
>= 5.8 - <= 6.4
Details on results:
PRELIMINARY TEST
- The preliminary estimate of water solubility was < 1.0 x 10E-04 g/L at 20.0 ± 0.5 °C.
- The pH of the solution was 6.7

DEFINITIVE TEST
- Typical chromatograms are attached.
- The mean peak areas relating to the standard and sample solutions are shown in Table 4.2 (attached).
- Concentration (g/L) of test item in the sample solutions is shown in Table 4.3 (below).

VALIDATION
- linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 100 mg/L. Results were satisfactory with a correlation coefficient of 1.000 being obtained.
- Triplicate recoveries, at a nominal concentration of 0.10 mg/mL were carried out in separate funnels.
- Glass double distilled water (200 mL) was spiked with 2.0 mL of spiking solution (approximately 10 mg/L test item in 10 mM formic acid in methanol).
- Sodium chloride (5g) was added and the sample was swirled to dissolve the NaCl.
- A recovery blank was prepared similarly without including the test item.
- Recover samples and blanks were then treated as described previously (extraction with 3 x 25 mL dichloromethane etc).
- The standards, standard blank, recovery samples and recovery blanks were then analysed as described previously.
- At the nominal concentration of 0.10 mg/L, a mean percentage recovery of 41.2 % was obtained (range 28.7 to 49.9 %).
- It was consequently concluded that recovery analysis for the sample procedure was adequate for the test.

TABLE 4.3 – CONCENTRATION OF TEST ITEM IN SAMPLE SOLUTIONS

Sample number

Time shaken at approximately 30 °C (hours)

Time equilibrated at 20 °C (hours)

Concentration (g/L)

Solution pH

1

72

24

< 1.0 x 10-4

5.8

2

48

24

< 1.0 x 10-4

6.0

3

24

24

< 1.0 x 10-4

6.4

Overall concentration = less than 1.0 x 10E-04 g/L at 20.0 ± 0.5 °C

Conclusions:
The water solubility (Daphnia medium) of the test item was determined to be < 1.0 x 10E-04 g/L at 20.0 ± 0.5 °C.
Executive summary:

GUIDELINE

The determination was carried out using the flask method and a procedure designed to be compatible with Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

The water solubility of the test item in glass double distilled water was determined to be < 1.0 x 10E-04 g/L at 20.0 ± 0.5 °C.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
11 October 2010 and 20 December 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
< 0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
0.2 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
30 °C
pH:
>= 7.3 - <= 7.6
Details on results:
PRELIMINARY TEST
- The preliminary estimate of water solubility was < 1.0 x 10E-04 g/L at 20.0 ± 0.5 °C.
- The pH of the solution was 6.7

DEFINITIVE TEST
- Typical chromatograms are attached.
- The mean peak areas relating to the standard and sample solutions are shown in Table 5.2 (attached).
- Concentration (g/L) of test item in the sample solutions is shown in Table 5.3 (below).

VALIDATION
- linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 100 mg/L. Results were satisfactory with a correlation coefficient of 1.000 being obtained.
- Triplicate recoveries, at a nominal concentration of 0.10 mg/mL were carried out in separate funnels.
- Reconstituted water (200 mL) was spiked with 2.0 mL of spiking solution (approximately 10 mg/L test item in 10 mM formic acid in methanol).
- Sodium chloride (5g) was added and the sample was swirled to dissolve the NaCl.
- A recovery blank was prepared similarly without including the test item.
- Recover samples and blanks were then treated as described previously (extraction with 3 x 25 mL dichloromethane etc).
- The standards, standard blank, recovery samples and recovery blanks were then analysed as described previously.
- At the nominal concentration of 0.10 mg/L, a mean percentage recovery of 46.0 % was obtained (range 27.0 to 58.9 %).
- It was consequently concluded that recovery analysis for the sample procedure was adequate for the test.

TABLE 5.3 – CONCENTRATION OF TEST ITEM IN SAMPLE SOLUTIONS

Sample number

Time shaken at approximately 30 °C (hours)

Time equilibrated at 20 °C (hours)

Concentration (g/L)

Solution pH

1

72

24

< 1.0 x 10-4

7.3

2

48

24

< 1.0 x 10-4

7.5

3

24

24

< 1.0 x 10-4

7.6
Conclusions:
The water solubility of the test item in reconstituted water (Daphnia medium) was determined to be < 1.0 x 10E-04 g/L at 20.0 ± 0.5 °C.
Executive summary:

GUIDELINE

The determination of test item solubility in reconstituted water (Daphnia medium) was carried out using the flask method and a procedure designed to be compatible with Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

The water solubility of the test item in reconstituted water (Daphnia medium) was determined to be < 1.0 x 10E-04 g/L at 20.0 ± 0.5 °C.

Description of key information

The water solubility of the test item was determined to be 0.566 g/L (monomer) and < 1 x 10E-04 g/L (dimers) at 20.0 ± 0.5 °C (OECD 105 and EU Method A.6).

Key value for chemical safety assessment

Water solubility:
0.566 mg/L
at the temperature of:
20 °C

Additional information

Key study

GUIDELINE

The determination was carried by the flask method using a procedure designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

The water solubility of the test item was determined to be 0.566 g/L (monomer) and < 1 x 10E-04 g/L (dimers) at 20.0 ± 0.5 °C.

Supporting studies

GUIDELINE

Determination of test item monomer component water solubility was performed using the flask method and a procedure designed to be compatible with Method A.6 Water Solutbility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

The water solubility of the test item monomer component was determined to be 0.566 g/L (monomer) at 20.0 ± 0.5 °C.

GUIDELINE

Determination of test item solubility in glass double distilled water was carried out using the flask method and a procedure designed to be compatible with Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

The water solubility of the test item in glass double distilled water was determined to be < 1.0 x 10E-04 g/L at 20.0 ± 0.5 °C.

GUIDELINE

Determination of test item solubility in reconstituted water (Daphnia medium) was carried out using the flask method and a procedure designed to be compatible with Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

The water solubility of the test item in reconstituted water (Daphnia medium) was determined to be < 1.0 x 10E-04 g/L at 20.0 ± 0.5 °C.