Registration Dossier
Registration Dossier
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EC number: 249-420-8 | CAS number: 29091-09-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,4-dichloro-1,3-dinitro-5-(trifluoromethyl)benzene
- EC Number:
- 249-420-8
- EC Name:
- 2,4-dichloro-1,3-dinitro-5-(trifluoromethyl)benzene
- Cas Number:
- 29091-09-6
- Molecular formula:
- C7HCl2F3N2O4
- IUPAC Name:
- 2,4-dichloro-1,3-dinitro-5-(trifluoromethyl)benzene
- Details on test material:
- Identification: 2,4 dichloro 3,5 dinitro benzotrifluoride
Description: solid
Purity: 96.4%
Stability of test article: Stable under storage conditions
Stability of test article dilution: 7 days at room temperature
Storage conditions: at room temperature away from direct sunlight.
Safety precautions: gloves, goggles and face mask,
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- polyethylene glycol
- Duration of exposure:
- 14 days
- Doses:
- 2000mg/kg body weight
- No. of animals per sex per dose:
- 5 females and 5 males
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred during the study.
- Clinical signs:
- other: In all animals, yellow staining, scabbing and scaling were observed on the treated skin. In four males and in two females, reversible alopecia was noted. In two females, scaling was evident until the end of the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The DL50 is > 2000 mg/kg body weight.
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