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EC number: 407-870-4 | CAS number: 97384-48-0 CITROWANIL B
Endpoint summary
Administrative data
Description of key information
The acute oral toxicity of Citrowanil B is 2024 mg/kg bw.
The acute dermal toxicity of Citrowanil B is > 2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 024 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Additional information
The product Citrowanil B M 2/585 Nr. 4 was tested in an acute toxicity study after one oral application at the dosages of 1, 2, 3 and 5 ml /kg body weight to the rat with a 14 day observation period according to OECD 401.
The following results were found:
The 48 hours LD50 was found at 3.6 ml of the product per kg of body weigt. Since some late mortalities did occur, the 14 days-LD50 is 2.2 ml/kg of body weight.
Considering the density of the test compound the LD 50 value is 2,024 mg/kg BW.
The slope function was measurable well (1.23).
The toxic symptomatic was marked by quick occuring abdominal ache syndrome, increased frequently of respiration, apathy, sedation and diminished readiness for reflexing. After few hours these symptoms changen from sedation to coma.
The surviving animals of dosage groups showed a clear reduced development of body weight; with increasing dosage animals gained less weight.
Macroscopical adspection during autopsy did not show alterations in the cases of acute mortalities and also not at final autopsy in the cranium and thorax. Intestinal was observed hyperemic small and large intestines in acute mortalities and at final autopsy only.
The Acute Dermal Toxicity of Citrowanil B was determined in compliance with OECD 402 (1987).
Citrowanil B was applied in a dose of 2000 mg per kg weight dermal in each case to 5 male and 5 female Albino-Sprague Dawley rats.
Under the condition of this experiment Citrowanil B did not show any mortality.
Therefore, the experiment was finished as a limit test (LD50 dermal mor than 2000 mg per kg weight).
Acute toxicological signs were found in one male rat with bloody urine only during the exposure period of the first day. In other rats no toxicological signs were found.
The body weight of all rats had a normal physiological growth. Only in the first day after the application variations were observed.
The post-mortem findings after euthanasia did not show any macroscopic organ changes.
Justification for classification or non-classification
The results of the acute oral toxicity study (LD50 = 2024 mg/kg bw) do not confirm the classification according to Regulation (EC) No 1272/2008, Annex VI, Table 3.1 and 3.2.
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