Registration Dossier
Registration Dossier
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EC number: 435-990-7 | CAS number: 371921-34-5
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From October 23 to December 8, 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- 1992
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Yellow 981
- IUPAC Name:
- Yellow 981
- Test material form:
- solid: particulate/powder
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Mixed into the test water as homogeneously as possible by ultrasonic treatment for 15 minutes and by intense stirring for 96 h at room temperature in the dark to dissolve a maximum concentration of the test item in the dispersion.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Test temperature:
- 21 - 22 °C
- pH:
- 8.0 - 8.1
- Dissolved oxygen:
- 8.2 - 8.5 mg O2/l, and thus always greater than 60 % oxygen saturation
- Nominal and measured concentrations:
- - Nominal concentrations: 100 mg/l only
- Measured concentrations: day 0: 0.170 mg/l; day 2: 0.114 mg/l; day 4: 0.091 mg/l; mean: 0.125 mg/l
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 0.125 mg/l mean measured
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 0.125 mg/l mean measured
- Details on results:
- No mortality or symptoms of toxicity occurred during the study period. Test item adsorbed onto glass of aquaria. Light yellow colouration caused by the test item was apparent throughout the study period.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- LC50 (96h) > 100 mg/l (nominal)
NOEC (96h) = 100 mg/l (nominal)
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