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EC number: 285-998-8
CAS number: 85186-15-8
substance was assayed for the mutagenicity by the Bacterial Reverse
Mutation Test. The test was performed according to the EU method B.13/14
Mutagenicity – Reverse mutation test using bacteria,which is analogous
to the OECD Guideline 471.
indicator Salmonella typhimurium strains TA 98, TA 100, TA 1535,
TA 1537 and one indicator Escherichia coli WP2 uvrA strain were
used. The test substance was diluted in water for injection and assayed
in doses of 100 - 2300 mg per plate, which were applied to plates in
volume of 0.1 mL.
were performed without as well as with metabolic activation with a
supernatant of rat liver and a mixture of cofactors. The first
experiments were performed without and the second experiments with 30
minutes of pre-incubation at 37±1 °C and shaking.
arrangement given above, the test substance, was non-mutagenic for all
the used tester strains without as well as with metabolic activation.
Pre-incubation had no influence on study results.
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