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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
August 28, 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Water solubility:
ca. 22.96 g/L
Temp.:
20 °C
pH:
ca. 7.66

Preliminary solubility result:

Reference samples and extract were first measured in the range 190 / 800 nm, so as to choose the right wavelength for quantitative measurements. Since the absorbance of the test solution was proportional to the concentration in the UV and visible spectra (fig. 1), the preliminary test result was considered for the final result calculations. The wavelength chosen was λ= 511.50 nm.

 

Test results:

Reference solutions were measured in the spectrophotometer in quantitative mode, thus generating a calibration curve (fig 2). The calibration curve was smooth and linear at every concentration. Considering that the preliminary test resulted in an absorbance of the same shape like the references, its value was considered for the 24 hours’ measurement (test 1). The following results were obtained after adjusting concentrations in proportion to the real weights:

Test 1 (24 hrs)

22.76

g/l

Test 2 (48 hrs)

23.71

g/l

Test 3 (96 hrs)

22.41

g/l

Average solubility

22.96

g/l

Standard deviation

0.67

pH mother solution

6.88

pH saturated solution

7.66

Conclusions:
The water solubility of the test substance is 22.96 g/l at 20 °C and pH 7.66
very soluble (> 10000 mg/L)
Executive summary:

The substance was tested for water solubility according to OECD guideline 105: Water solubility. The water solubility of the test substance is 22.96 g/l at 20 °C and pH 7.66

Description of key information

Water solubility = 22.96 g/l

Key value for chemical safety assessment

Water solubility:
22.96 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test substance is 22.96 g/l at 20 °C and pH 7.66, as determined by the flask method