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EC number: 201-497-9 | CAS number: 83-73-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Link to relevant study records
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
- Species:
- other: Rattus norvegicus
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- other: no data
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Dose descriptor:
- other: not specified
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Dose descriptor:
- LOEL
- Generation:
- F2
- Effect level:
- 182.553 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Reproductive effects observed:
- not specified
- Treatment related:
- not specified
- Conclusions:
- The two generation reproductive toxicity LOEL (Lowest observed effect level) of diiodohydroxyquinoline in Rattus norvegicus was observed at a dose concentration of 182.5526 mg/kg bw/day.This indicates that diiodohydroxyquinoline shall not exhibit toxic effect to Rattus norvegicus
below the above mentioned dose. - Executive summary:
The two generation reproductive toxicity LOEL (Lowest observed effect level) of diiodohydroxyquinoline in Rattus norvegicus was observed at a dose concentration of 182.5526 mg/kg bw/day.This indicates that diiodohydroxyquinoline shall not exhibit toxic effect to Rattus norvegicus
below the above mentioned dose.
Reference
The
prediction was based on dataset comprised from the following
descriptors: LOEL
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((("a"
and "b" )
and ("c"
and (
not "d")
)
)
and ("e"
and "f" )
)
Domain
logical expression index: "a"
Similarity
boundary:Target:
c1(I)c(O)c2c(c(I)c1)cccn2
Threshold=50%,
Dice(Atom pairs)
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as No superfragment by
Superfragments
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding by OECD
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Acetates OR MA: Direct Acylation
Involving a Leaving group OR Mechanistic Domain: Acylation by Protein
binding by OECD
Domain
logical expression index: "e"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 3.29
Domain
logical expression index: "f"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 4.01
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
Additional information
Short description of key information:
The two generation reproductive toxicity LOEL (Lowest observed effect level) of diiodohydroxyquinoline in Rattus norvegicus was observed at a dose concentration of 182.5526 mg/kg bw/day.This indicates that diiodohydroxyquinoline shall not exhibit toxic effect to Rattus norvegicus
below the above mentioned dose. The other result also predicts the ERBA effect level to be equal to 0.075 which could be a possible pointer towards the chemical not being toxic to reproduction in low levels. Thus, the weight of evidence approach does not suggest reprotixicity within the concentration mentioned in the study results.
Justification for selection of Effect on fertility via oral route:
Model is considered relaible by OECD
Effects on developmental toxicity
Description of key information
The fetotoxicity LOEL (Lowest observed effect level) of diiodohydroxyquinoline in Rattus norvegicus and Oryctolagus cuniculus was observed at a dose concentration of 640.9886 mg/kg bw/day.This indicates that diiodohydroxyquinoline shall not exhibit toxic effect to Rattus norvegicus and Oryctolagus cuniculus below the above mentioned dose. The DAmish EPA database also attributes negative teratogenecity to diiodohydroxyquinoline in low concentrations.
Link to relevant study records
- Endpoint:
- developmental toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
- Species:
- other: Rattus norvegicus;Oryctolagus cuniculus
- Strain:
- not specified
- Route of administration:
- other: no data
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Dose descriptor:
- other: not specified
- Based on:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
- Abnormalities:
- not specified
- Localisation:
- not specified
- Description (incidence and severity):
- not specified
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no data
- Dose descriptor:
- LOEL
- Effect level:
- 640.989 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- other: fetotoxicity
- Abnormalities:
- not specified
- Localisation:
- other: not specified
- Description (incidence and severity):
- not specified
- Developmental effects observed:
- not specified
- Treatment related:
- not specified
- Conclusions:
- The fetotoxicity LOEL (Lowest observed effect level) of diiodohydroxyquinoline in Rattus norvegicus and Oryctolagus cuniculus was observed at a dose concentration of 640.9886 mg/kg bw/day.This indicates that diiodohydroxyquinoline shall not exhibit toxic effect to Rattus norvegicus and Oryctolagus cuniculus below the above mentioned dose.
- Executive summary:
The fetotoxicity LOEL (Lowest observed effect level) of diiodohydroxyquinoline in Rattus norvegicus and Oryctolagus cuniculus was observed at a dose concentration of 640.9886 mg/kg bw/day.This indicates that diiodohydroxyquinoline shall not exhibit toxic effect to Rattus norvegicus and Oryctolagus cuniculus below the above mentioned dose.
Reference
The
prediction was based on dataset comprised from the following
descriptors: LOEL
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(("a"
and ("b"
and (
not "c")
)
)
and ("d"
and "e" )
)
Domain
logical expression index: "a"
Similarity
boundary:Target:
c1(I)c(O)c2c(c(I)c1)cccn2
Threshold=50%,
Dice(Atom pairs)
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding by OASIS
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as alpha,beta-carbonyl compounds
with polarized double bonds OR alpha-activated haloalkanes OR Carbamates
OR MA: Direct acylation involving a leaving group OR MA: Michael
addition on conjugated systems with electron withdrawing group OR MA:
Nucleophilic substitution at sp3 Carbon atom OR MA: Pyrazolones and
pyrazolidinones derivatives OR Mechanistic Domain: Acylation OR
Mechanistic Domain: Michael addition OR Mechanistic Domain: Schiff base
formation OR Mechanistic Domain: SN2 OR N-acylamides OR Pyrazolones and
pyrazolidinones by Protein binding by OASIS
Domain
logical expression index: "d"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 3.02
Domain
logical expression index: "e"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 4.83
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- chronic
- Species:
- rat
- Quality of whole database:
- Model considered relaible by OECD supported by data from the Danish EPA that is considered to be an authoritative source of information
Additional information
Justification for selection of Effect on developmental toxicity: via oral route:
Model considered relaible by OECD
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
