Registration Dossier
Registration Dossier
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EC number: 201-497-9 | CAS number: 83-73-8
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline
- Author:
- Surendra Ghaskadbi, V.G. Vaidya
- Year:
- 1 989
- Bibliographic source:
- Mutation Research/Genetic Toxicology Volume 222, Issue 3, March 1989, Pages 219-222
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: not available
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Diiodohydroxyquinoline
- EC Number:
- 201-497-9
- EC Name:
- Diiodohydroxyquinoline
- Cas Number:
- 83-73-8
- Molecular formula:
- C9H5I2NO
- IUPAC Name:
- 5,7-diiodoquinolin-8-ol
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: oral
- Vehicle:
- no data
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- no data
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
80 mg/kg
Basis:
- Control animals:
- not specified
- Positive control(s):
- no data
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- not specified
- Toxicity:
- not examined
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
